Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis.

@article{Beringer2008LackOE,
  title={Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis.},
  author={Paul M. Beringer and Jane Kriengkauykiat and Xiyun Zhang and Levita Hidayat and Shanshan Liu and Stan Louie and Tim W Synold and Gilbert J. Burckart and P. Ameeta Rao and Bertrand Shapiro and Mark Gill},
  journal={Pharmacotherapy},
  year={2008},
  volume={28 7},
  pages={883-94}
}
STUDY OBJECTIVE To determine whether upregulation of P-glycoprotein is responsible for the enhanced renal clearance of dicloxacillin in patients with cystic fibrosis. DESIGN Single-center, prospective, open-label, randomized, three-part crossover pharmacokinetic study. SETTING General clinical research center. SUBJECTS Eleven patients with cystic fibrosis and 11 age-matched healthy volunteers. INTERVENTION All subjects received a single oral dose of dicloxacillin 500 mg alone… CONTINUE READING
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