Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.

@article{Lies2013LackOE,
  title={Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.},
  author={Barbara Lies and Dieter Groneberg and Stepan P Gambaryan and Andreas Friebe},
  journal={British journal of pharmacology},
  year={2013},
  volume={170 2},
  pages={317-27}
}
BACKGROUND AND PURPOSE Nitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-dependent NO effects. Consequently, NO-induced reactions seen in the presence of these inhibitors commonly serve as an affirmation of cGMP independence. EXPERIMENTAL APPROACH We evaluated the use of… CONTINUE READING

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