Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in postmenopausal breast cancer risk.

@article{Rebbeck2007LackOE,
  title={Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in postmenopausal breast cancer risk.},
  author={Timothy R. Rebbeck and Andrea B. Troxel and Ekaterina G Shatalova and Rebecca Blanchard and Sandra A. Norman and Greta R. Bunin and Angela DeMichele and Rita Schinnar and Jesse A Berlin and Brian L. Strom},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2007},
  volume={16 6},
  pages={
          1318-20
        }
}
Postmenopausal use of combined hormone replacement therapy (CHRT) containing both estrogens and progestins has been associated with increased breast cancer risk (1, 2). There is also evidence that genetic variants in candidate estrogen metabolism genes influence the disposition of exogenous estrogen. The genes involved in the disposition of estrogen are well known, and include catechol-O -methyltransferase (COMT), the sulfotransferases SULT1A1 and SULT1E1 , and members of the cytochrome P50… CONTINUE READING

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