Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites.

@article{Little1996LackOD,
  title={Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites.},
  author={Karley Y. Little and J Gorebig and F Ivy Carroll and J Mapili and James H. Meador-Woodruff},
  journal={Brain research},
  year={1996},
  volume={742 1-2},
  pages={313-6}
}
Depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (DAT). One possible mechanism for the cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine. To test this hypothesis, the present experiment examined in rats… CONTINUE READING