Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9 * 3 allele

@article{Shimamoto2000LackOD,
  title={Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9 * 3 allele},
  author={J. Shimamoto and Ichiro Ieiri and Akinori Urae and Miyuki Kimura and Shin Irie and Takahiro Kubota and Kan Chiba and Takashi Ishizaki and Kenji Otsubo and Shun Higuchi},
  journal={European Journal of Clinical Pharmacology},
  year={2000},
  volume={56},
  pages={65-68}
}
Objectives: Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. Methods: A single dose of diclofenac was administered orally to 12 healthy subjects in whom the genotype of CYP2C9 had been… CONTINUE READING