Lack of diagnostic and prognostic utility of circulating plasma myeloperoxidase concentrations in patients presenting with dyspnea.

@article{Shah2009LackOD,
  title={Lack of diagnostic and prognostic utility of circulating plasma myeloperoxidase concentrations in patients presenting with dyspnea.},
  author={Keyur Bharat Shah and Willem Johan Kop and Robert H M Christenson and Deborah B. Diercks and D. Chien-Liang Kuo and Sue Henderson and Karen Hanson and Mandeep R Mehra and Christopher deFilippi},
  journal={Clinical chemistry},
  year={2009},
  volume={55 1},
  pages={59-67}
}
BACKGROUND Plasma myeloperoxidase (MPO), an inflammatory biomarker, is associated with increased mortality in patients with acute coronary syndrome or chronic left ventricular systolic dysfunction. We sought to assess the diagnostic accuracy of MPO for acute decompensated heart failure (ADHF) and its prognostic value for patients with acute dyspnea. METHODS In a prospective, observational study conducted in 5 US centers, 412 patients [mean (SD) age, 58 (14) years; 39% women] presenting with… CONTINUE READING

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