Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia.

@article{Meeker1988LackOD,
  title={Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia.},
  author={Timothy C. Meeker and J. Christopher Grimaldi and Rose O'Rourke and Julius Loeb and Gunnar Juliusson and Stefan Einhorn},
  journal={Journal of immunology},
  year={1988},
  volume={141 11},
  pages={
          3994-8
        }
}
Monoclonal human B cell tumors are a model system for the study of somatic hypermutation of the Ig genes of humans. It was previously shown that a number of B cell lymphomas exhibited striking V region point mutation, hypothesized to result from the somatic hypermutation mechanism. In this study we have extended the analysis to chronic lymphocytic leukemia. We have cloned and sequenced the productive Vh representing five different cells from a monoclonal chronic lymphocytic leukemia. All five… CONTINUE READING

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