Lack of desensitization and enhanced efficiency of calcium channel promoter in conscious dogs with heart failure.


The goal of this study was to compare responses to a calcium promoter, BAY y 5959, and dobutamine (Dob) in heart failure (HF). Dogs ( n = 9) were chronically instrumented and studied in the conscious state before and after pacing-induced HF. In the control state, BAY y 5959 (20 μg ⋅ kg-1 ⋅ min-1) increased the first derivative of left ventricular (LV… (More)
DOI: 10.1152/ajpheart.1998.275.6.H2219


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