Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys.


It is well known that an alteration in insulin activation of skeletal muscle glycogen synthase is associated with insulin resistance. To determine whether this defect in insulin action is specific to skeletal muscle, or also present in liver, simultaneous biopsies of these tissues were obtained before and during a euglycemic hyperinsulinemic clamp in… (More)


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