Lack of cross‐resistance to FF‐10501, an inhibitor of inosine‐5′‐monophosphate dehydrogenase, in azacitidine‐resistant cell lines selected from SKM‐1 and MOLM‐13 leukemia cell lines

Abstract

Resistance to azacitidine is a major issue in the treatments of myelodysplastic syndrome and acute myeloid leukemia, and previous studies suggest that changes in drug metabolism are involved in the resistance. Therefore, drugs with mechanisms resistant or alternative to such metabolic changes have been desired for the treatment of resistant disease. We… (More)
DOI: 10.1002/prp2.206

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Cite this paper

@inproceedings{Murase2016LackOC, title={Lack of cross‐resistance to FF‐10501, an inhibitor of inosine‐5′‐monophosphate dehydrogenase, in azacitidine‐resistant cell lines selected from SKM‐1 and MOLM‐13 leukemia cell lines}, author={Motohiko Murase and Hiroyuki Iwamura and Kensuke Komatsu and Motoki Saito and Toshihiko Maekawa and Takaaki Nakamura and Takuya Yokokawa and Yasuhiro Shimada}, booktitle={Pharmacology research & perspectives}, year={2016} }