Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells.

@article{OByrne2000LackOC,
  title={Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells.},
  author={D O'Byrne and David M Sansom},
  journal={Immunology},
  year={2000},
  volume={100 2},
  pages={225-30}
}
Resting T cells require a signal transduced through their antigen-specific T-cell receptor (TCR) and an antigen-independent costimulatory signal in order to proliferate and become activated. Ligation of the CD28 receptor costimulates T-cell proliferation and is critical to correct T-cell function. A putative effector of CD28-mediated costimulation is the sphingomyelinase enzyme, which generates the potent second messenger ceramide. We have examined the role of sphingomyelinase and C2 ceramide… CONTINUE READING