Lack of correlation of hypotensive effects with prevention of cardiac hypertrophy by perindopril after ligation of rat coronary artery.

@article{Chiba1994LackOC,
  title={Lack of correlation of hypotensive effects with prevention of cardiac hypertrophy by perindopril after ligation of rat coronary artery.},
  author={Katsuyoshi Chiba and Sachiko Moriyama and Yutaka Ishigai and Akiko Fukuzawa and Kaoru Irie and Toshiro Shibano},
  journal={British journal of pharmacology},
  year={1994},
  volume={112 3},
  pages={837-42}
}
1. The present study was designed to test the hypothesis that beneficial effects of angiotensin converting enzyme (ACE)inhibitors are independent of a fall in blood pressure in rat experimental heart failure following coronary ligation. 2. The animals were assigned randomly to six groups; sham operation, controls subjected to coronary ligation (control), coronary ligation plus chronic treatment with ACE inhibitors at non- and hypotensive doses; perindopril (0.2 or 2 mg kg-1 day-1) or enalapril… CONTINUE READING