Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis.

@article{Lafforgue1995LackOC,
  title={Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis.},
  author={Pierre Lafforgue and S. Monjanel-Mouterde and Alain Durand and Jacques Catalin and Paolo Acquaviva},
  journal={The Journal of rheumatology},
  year={1995},
  volume={22 5},
  pages={844-9}
}
OBJECTIVE To determine if the variability in the efficacy of methotrexate (MTX) in rheumatoid arthritis (RA) is correlated with its pharmacokinetics. METHODS MTX pharmacokinetics was evaluated in 46 patients with RA starting a weekly intramuscular low dose MTX treatment. The patients were divided into 32 responders and 14 nonresponders to MTX according to… CONTINUE READING