Lack of correlation between natural killer activity and tumor growth control in nude mice with different immune defects.

@article{Fodstad1984LackOC,
  title={Lack of correlation between natural killer activity and tumor growth control in nude mice with different immune defects.},
  author={Oystein Fodstad and Carl T. Hansen and Grace B. Cannon and C N Statham and Gary R. Lichtenstein and Michael R. Boyd},
  journal={Cancer research},
  year={1984},
  volume={44 10},
  pages={4403-8}
}
To elucidate the in vivo role of natural killer (NK) cells, the growth of several murine and human tumors was studied in four variants of athymic, nude mice with different levels of NK activity. Beige-nude mice, homozygous for both the beige and the nude genes, had very low levels of NK activity, and their response to the B-cell mitogen, bacterial lipopolysaccharide, was lower than that of high-NK, adult NIH nude mice. Young and adult NIH nudes had different NK levels and showed different… CONTINUE READING

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