Lack of correlation between in silico projection of function and quantitative real-time PCR-determined gene expression levels in colon tissue

@inproceedings{Penney2013LackOC,
  title={Lack of correlation between in silico projection of function and quantitative real-time PCR-determined gene expression levels in colon tissue},
  author={Rosalind Brigham Penney and Abbie Lundgreen and Aiwei Yao-Borengasser and Vineetha Koroth-Edavana and Suzanne Williams and Roger K Wolff and Martha L. Slattery and Susan A Kadlubar},
  booktitle={Pharmacogenomics and personalized medicine},
  year={2013}
}
There are a number of in silico programs that use algorithms and external web sources to predict the effect of single nucleotide polymorphisms (SNPs). While many of these programs have been shown to predict accurately the effect of SNPs in functional areas of the gene, such as 5' upstream or coding regions, empiric research may be warranted to confirm the functional consequences of SNPs that are predicted to have little to no effect. We compared predictions from FASTSNP (Function Analysis and… CONTINUE READING
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