Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase.

@article{Asgari2011LackOC,
  title={Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase.},
  author={Shadnaz Asgari and Paul M. Vespa and Marvin Bergsneider and Xiao Hu},
  journal={Physiological measurement},
  year={2011},
  volume={32 10},
  pages={1639-51}
}
Lactate/pyruvate ratio (LPR) from microdialysis is a well-established marker of cerebral metabolic crisis. For brain injury patients, abnormally high LPR could indicate cerebral ischemia or failure of O(2) uptake. However, there is a debate on the primary factor responsible for LPR increase. Exploiting the potential of using the morphology of a high temporal resolution signal such as intracranial pulse (ICP) to characterize cerebrovascular changes, a data analysis experiment is taken to test… CONTINUE READING