Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.

@article{Lofgren2011LackOC,
  title={Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.},
  author={J. Lofgren and M. Whary and Z. Ge and S. Muthupalani and N. Taylor and Melissa W. Mobley and A. Potter and A. Varr{\'o} and D. Eibach and S. Suerbaum and T. Wang and J. Fox},
  journal={Gastroenterology},
  year={2011},
  volume={140 1},
  pages={
          210-20
        }
}
BACKGROUND & AIMS Transgenic FVB/N insulin-gastrin (INS-GAS) mice have high circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal intraepithelial neoplasia (GIN) with 80% prevalence 6 months after Helicobacter pylori infection. GIN is associated with gastric atrophy and achlorhydria, predisposing mice to nonhelicobacter microbiota overgrowth. We determined if germfree INS-GAS mice spontaneously develop GIN and if H pylori accelerates GIN in gnotobiotic INS… Expand
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