Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system.

@article{Carvalho2013LackOC,
  title={Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system.},
  author={Livia Carvalho and Juan Pablo Garc{\'i}a de la Torre and Alex S. Papadopoulos and Lucia Poon and M{\'a}rio Francisco Juruena and Kalypso Markopoulou and Anthony J Cleare and Carmine M Pariante},
  journal={Journal of affective disorders},
  year={2013},
  volume={148 1},
  pages={
          136-40
        }
}
Despite the evidence of an association between depression and increased inflammatory markers, still little is known in relation to the most severe cases of the disorder i.e., those who fail to respond to antidepressants. We have assessed the cytokine profile and cortisol levels in 21 healthy controls (HC) and 19 medicated patients with depression with treatment-resistance (TRD) moderately ill. As an initial exploratory analysis, we have also related cytokine profile to the patient's clinical… CONTINUE READING

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