Lack of clinical association and effect of peripheral WBC counts on immune cell function test in kidney transplant recipients with T-cell depleting induction and steroid-sparing maintenance therapy.

@article{Sageshima2014LackOC,
  title={Lack of clinical association and effect of peripheral WBC counts on immune cell function test in kidney transplant recipients with T-cell depleting induction and steroid-sparing maintenance therapy.},
  author={Junichiro Sageshima and Gaetano Ciancio and Linda J Chen and Takehiko Dohi and Ashraf El-Hinnawi and Siegfredo Paloyo and Jeffrey J Gaynor and Adela D Mattiazzi and Giselle Guerra and Warren L. Kupin and David Roth and Phillip Ruiz and George William Burke},
  journal={Transplant immunology},
  year={2014},
  volume={30 2-3},
  pages={88-92}
}
The Cylex ImmuKnow assay measures the amount of stimulated ATP production by CD4+ T-cells, and has been used clinically, trying to predict rejection and infection episodes. However, predictive values of this assay after induction therapy with steroid-sparing maintenance protocols are unclear. In this single-center cohort study, we analyzed renal transplant recipients who received T-cell depleting+/-anti-IL2 receptor antibodies and tacrolimus/mycophenolate maintenance without steroids. A total… CONTINUE READING