Lack of chloroform-induced DNA repair in vitro and in vivo in hepatocytes of female B6C3F1 mice.

@article{Larson1994LackOC,
  title={Lack of chloroform-induced DNA repair in vitro and in vivo in hepatocytes of female B6C3F1 mice.},
  author={Jarrod L. Larson and Catherine S. Sprankle and Byron E. Butterworth},
  journal={Environmental and molecular mutagenesis},
  year={1994},
  volume={23 2},
  pages={
          132-6
        }
}
Chloroform has been shown to induce hepatocellular carcinomas in female B6C3F1 mice when administered by gavage, but not when given in drinking water. When administered in corn oil at the carcinogenic doses of 238 and 477 mg/kg, chloroform induced necrosis and sustained regenerative cell proliferation in the liver. To investigate the mode of action of tumor induction in the target cells, the ability of chloroform to induce unscheduled DNA synthesis (UDS) was examined in the in vitro and in vivo… CONTINUE READING
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