Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.

@article{Kitamura2006LackOC,
  title={Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.},
  author={Yasuki Kitamura and Megumi Yamagishi and Kazushi Okazaki and Tatsuo Umemura and Takayoshi Imazawa and Akiyoshi Nishikawa and W Matsumoto and Masao Hirose},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2006},
  volume={44 2},
  pages={
          271-7
        }
}
alpha-Eleostearic acid is one of the conjugated linolenic acids from tung oil, which is obtained from the seeds of Aleurites fordii. The effects of dietary alpha-eleostearic acid (18:3, n-5) on the post-initiation period of 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis were examined using female Sprague-Dawley (SD) rats. For initiation, rats were given subcutaneous injections of 40mg/kg body weight (5 times) and 20mg/kg body… CONTINUE READING