Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

@article{Bruno1998LackOC,
  title={Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation},
  author={Alain Pierre Bruno and Guy Laurent and Dietrich Averbeck and C Saura Demur and Jacques E Bonnet and Ali Betta{\"i}eb and Thierry Levade and J P Jaffr{\'e}zou},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={172-182}
}
The mechanism(s) by which ionizing radiation (IR) induces cell death is of fundamental importance in understanding cell sensitivity and resistance. Here we evaluated the response to IR of two subclones of the autonomous human erythromyeloblastic cell line TF-1: TF-1-34 (which expresses CD34) and TF-1-33 (which lacks CD34). In clonogenic assays, TF-1-34 cells were found to be relatively less sensitive to IR compared to TF-1-33 cells based on the D0 determination (3.01 vs 1.56 Gy). Furthermore… CONTINUE READING