Lack of both oxygen and glucose contributes to I/R-induced changes in cardiac SR function.

@article{Temsah2002LackOB,
  title={Lack of both oxygen and glucose contributes to I/R-induced changes in cardiac SR function.},
  author={Rana M. Temsah and Thomas Netticadan and Ken-ichi Kawabata and Naranjan S. Dhalla},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 4},
  pages={C1306-12}
}
Although ischemia-reperfusion (I/R) has been shown to depress cardiac performance and sarcoplasmic reticulum (SR) function, the mechanisms underlying these alterations are poorly understood. Because lack of oxygen and substrate deprivation are known to occur during the ischemic phase, we examined the effects of reperfusion on cardiac performance and SR function in hearts subjected to hypoxia and substrate lack. For this purpose, isolated rat hearts were perfused with hypoxic and/or glucose-free… CONTINUE READING

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