Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice.

@article{Luna2002LackOB,
  title={Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice.},
  author={Rosa M Licon Luna and Eva Y.-H.P Lee and Arno M{\"u}llbacher and Robert V. Blanden and Rod Langman and Mario Lobigs},
  journal={Journal of virology},
  year={2002},
  volume={76 7},
  pages={3202-11}
}
The mechanism by which encephalitic flaviviruses enter the brain to inflict a life-threatening encephalomyelitis in a small percentage of infected individuals is obscure. We investigated this issue in a mouse model for flavivirus encephalitis in which the virus was administered to 6-week-old animals by the intravenous route, analogous to the portal of entry in natural infections, using a virus dose in the range experienced following the bite of an infectious mosquito. In this model, infection… CONTINUE READING

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