Lack of bone neoplasms and persistence of bone efficacy in cynomolgus macaques after long-term treatment with teriparatide [rhPTH(1-34)].

@article{Vahle2008LackOB,
  title={Lack of bone neoplasms and persistence of bone efficacy in cynomolgus macaques after long-term treatment with teriparatide [rhPTH(1-34)].},
  author={John L Vahle and Ulrich Zuehlke and Allen L Schmidt and Michael Westmore and Peiqi Chen and Masahiko Sato},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 12},
  pages={2033-9}
}
In rats, teriparatide [rhPTH(1-34)] causes marked increases in bone mass and osteosarcoma. In primates, teriparatide causes lesser increases in bone mass, and osteosarcomas have not been reported. Previous studies in primates were not designed to detect bone tumors and did not include a prolonged post-treatment observation period to determine whether tumors would arise after cessation of treatment. Ovariectomized (OVX), skeletally mature, cynomolgus monkeys (n = 30 per group) were given… CONTINUE READING

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