Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat

@article{Weir1994LackOB,
  title={Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat},
  author={M. Lynn Weir and U. Honrath and T. Geoffrey Flynn and Harald Sonnenberg},
  journal={Regulatory Peptides},
  year={1994},
  volume={53},
  pages={111-122}
}
In addition to atrial natriuretic peptide (ANP99-126) itself, linear peptide fragments from its N-terminal prohormone segment (pro-ANP) have been reported to have biological activity. In vivo, diuresis and natriuresis, as well as hypotension have been observed. In vitro, sodium uptake into medullary collecting duct cells was inhibited, and tone of vascular smooth muscle was reduced, associated with activation of guanylate cyclase. Such previous studies have used heterologous peptides and… CONTINUE READING