Lack of associations between polymorphisms in SOD2 (rs2758331), NOS3 (rs1808593), PPARδ (rs9794 and rs10865710) and the risk of osteoarthritis in a Chinese Han population: a case-control study

@article{Zhang2019LackOA,
  title={Lack of associations between polymorphisms in SOD2 (rs2758331), NOS3 (rs1808593), PPAR$\delta$ (rs9794 and rs10865710) and the risk of osteoarthritis in a Chinese Han population: a case-control study},
  author={Le-Cheng Zhang and Yong Hu and Cong Sui},
  journal={Chinese Medical Journal},
  year={2019},
  volume={132},
  pages={1113 - 1114}
}
Recently, increasing evidence suggested that the oxidative stress plays a critical role during OA development, and high levels of reaction oxygen species (ROS) could lead to greater lipid peroxidation, mtDNA damage, and signaling pathways’ activation. All those changes could promote cartilage degradation and cause the cleavage of collagen and hyaluronan.SOD2, eNOS, and PPARd have been reported as important genes to influence ROS process. However, no studies have yet evaluated the modifying… Expand
Anti-inflammatory activity of Radix Angelicae biseratae in the treatment of osteoarthritis determined by systematic pharmacology and in vitro experiments
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Functional enrichment analysis indicated that Radix Angelicae biseratae confers pharmacological efficacy towards OA through exerting anti-inflammatory effects and immune regulation. Expand

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PPARd (rs9794 and rs10865710) and the risk of osteoarthritis in a Chinese Han population: a case-control study
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