Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.

@article{Balada2006LackOA,
  title={Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.},
  author={Eva Balada and Carmen Pilar Sime{\'o}n-Aznar and Silvia Serrano-Acedo and Luis Mart{\'i}nez-Lostao and Albert Selva-O'Callaghan and Vicente Fonollosa-Pl{\'a} and Miquel Vilardell-Tarr{\'e}s},
  journal={Clinical and experimental rheumatology},
  year={2006},
  volume={24 3},
  pages={321-4}
}
OBJECTIVE It has recently been reported that some autoimmune diseases seem to be associated with a functional polymorphism in PTPN22, a gene which encodes a phosphatase known to be important in T-cell signaling. The aim of our study was to check for the prevalence of the PTPN22 R620W polymorphism in patients with systemic sclerosis. METHODS DNA samples from 54 systemic sclerosis patients and 55 healthy controls were obtained from peripheral blood and genotyping was performed by means of a… CONTINUE READING

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