Lack of association of apolipoprotein E allele epsilon 4 with late-onset Alzheimer's disease among Finnish centenarians.

@article{Sobel1995LackOA,
  title={Lack of association of apolipoprotein E allele epsilon 4 with late-onset Alzheimer's disease among Finnish centenarians.},
  author={Eugene L. Sobel and Jukka Louhija and Raimo O Sulkava and Zoreh Davanipour and Kimmo K. Kontula and Helena E. Miettinen and M. J. Tikkanen and Katariina Kainulainen and Reijo Sakari Tilvis},
  journal={Neurology},
  year={1995},
  volume={45 5},
  pages={903-7}
}
No association between Alzheimer's disease (AD) and apolipoprotein E type epsilon 4 (ApoE epsilon 4) phenotype was found among centenarians in Finland (N = 179). The data are based on ascertainment of all centenarians in Finland in 1991. All examinations were conducted during 1991. The diagnoses of dementia and AD were based on clinical grounds, conforming to DSM-III-R and NINCDS-ADRDA criteria. The percentage of ApoE epsilon 4 alleles among the centenarians was 8.7% (31 of 358 alleles). This… CONTINUE READING