Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.

  title={Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.},
  author={Tatiana Foroud and Leah Wetherill and Danielle M Dick and Victor M. Hesselbrock and John J I Nurnberger and John R. Kramer and Jay A. Tischfield and Marc A Schuckit and Laura J. Bierut and Xiaoling Xuei and Howard J. Edenberg},
  journal={Alcoholism, clinical and experimental research},
  volume={31 11},
OBJECTIVE To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. METHODS Single nucleotide polymophisms (SNPs) were genotyped in a sample of 219 multiplex alcohol-dependent families of European American descent from the Collaborative Study on the Genetics of Alcoholism (COGA). Family-based tests of… CONTINUE READING


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