Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.


BACKGROUND The apolipoprotein E epsilon 4 (ApoE epsilon 4) allele is associated with an increased risk for development of Alzheimer disease (AD). We hypothesized that polymorphisms in proteins that interact with ApoE also might have an impact on the likelihood of AD developing. We examined a polymorphism in the gene for the low-density lipoprotein receptor… (More)


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