Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia.

@article{Deligezer2007LackOA,
  title={Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia.},
  author={Ugur Deligezer and Ebru E. Akisik and Nejat Dalay},
  journal={Anticancer research},
  year={2007},
  volume={27 4B},
  pages={2453-6}
}
BACKGROUND Recent studies suggest that single nucleotide polymorphisms in different genes may modulate the susceptibility to chronic myelogenous leukaemia (CML). Here, the association of the common XRCC1 gene polymorphism Arg399Gln at codon 399 in CML was investigated. PATIENTS AND METHODS Genotyping was performed by melting curve analysis in samples from peripheral blood or bone marrow. RESULTS The frequency of the variant allele 399Gln was similar between the control group and the… CONTINUE READING

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