Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice.

Abstract

To evaluate the role of V beta 8+ T cells in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice, we treated them with the F23.1 anti-V beta 8 monoclonal antibody (mAb) from birth to 4 months of age. Here we report that almost complete depletion of V beta 8+ T cells by the F23.1 mAb treatment neither inhibited nor delayed the development of hypergammaglobulinemia, autoantibody production and autoimmune glomerulonephritis in MRL-lpr/lpr mice. In addition, the F23.1 mAb treatment did not prevent the development of lymphadenopathy and the generation of a CD4-CD8- double-negative T cell subset, characteristically accumulating in lpr lymph nodes. Our results strongly argue against the idea that the V beta 8+ T cells play a critical role in the development of lupus-like autoimmune syndrome in MRL-lpr/lpr mice.

Cite this paper

@article{Fossati1994LackOA, title={Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice.}, author={Luca Fossati and R. Merino and Masahiro Iwamoto and Robert Lemoine and Shozo Izui}, journal={European journal of immunology}, year={1994}, volume={24 7}, pages={1717-20} }