Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study

@inproceedings{Smith2012LackOA,
  title={Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study},
  author={Christopher G. Smith and Paul Lochhead and Umesh Basavaraju and Georgina L Hold and Nicky Fyfe and Graeme I. Murray and Emad M. El-Omar},
  booktitle={BMC Research Notes},
  year={2012}
}
Prostate stem cell antigen (PSCA) has been implicated in the pathogenesis of several solid tumours, either due to changes in protein expression, or through association with the rs2294008 polymorphism in the PSCA gene. To our knowledge, the role of PSCA in the development of colorectal neoplasia has not been explored. We performed a genotyping study to assess for associations between the rs2294008 polymorphism and risk of adenomatous polyps and colorectal cancer. DNA samples were available from… CONTINUE READING

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Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

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