Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies

@article{Gu2009LackOA,
  title={Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case–control studies},
  author={Dongying Gu and Meilin Wang and Zhengdong Zhang and Jinfei Chen},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={122},
  pages={527-531}
}
The functional Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case–control studies, including 6,804 breast cancer cases and 6,725 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant… CONTINUE READING

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Synergistic effects of polymorphisms in dna repair genes and endogenous estrogen exposure on female breast cancer risk

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