Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma.

@article{Yuan2008LackOA,
  title={Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma.},
  author={Xiaoyan Yuan and Gangqiao Zhou and Yun Zhai and Weimin Xie and Ying Cui and Jia Cao and Lianteng Zhi and Hong-Xing Zhang and Hao Yang and Xiaoai Zhang and Wei Qiu and Yong Peng and XiuMei Zhang and Ling Yu and Xia Xia and Fuchu He},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 12},
  pages={3621-7}
}
Estrogens have been proposed to act as tumor promoters and induce hepatocarcinogenesis. Recently, we observed a significant association between the risk for hepatocellular carcinoma and the polymorphisms of the estrogen receptor (ESR) alpha (ESR1) gene, supporting the hypothesis of involvement for the estrogen-ESR axis in the estrogen-induced hepatocarcinogenesis. In this study, based on another hypothesis in which estrogen metabolites can directly cause DNA damage and affect tumor initiation… CONTINUE READING

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