Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders.

@article{Hettema2008LackOA,
  title={Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders.},
  author={John M Hettema and Seon-Sook An and Michael C. Neale and Edwin J. C. G. van den Oord and Kenneth S. Kendler and Xiangning Chen},
  journal={Psychiatric genetics},
  year={2008},
  volume={18 2},
  pages={73-9}
}
OBJECTIVE Ion channels are involved in a wide range of central nervous system functions and have been implicated in several neuropsychiatric disorders. Rodent studies suggest that the acid-sensing ion channel, ASIC1, may play a role in fear conditioning, a model for human anxiety disorders. In this study, we examined, for the first time, the human analog of ASIC1, the amiloride-sensitive cation channel 2 (ACCN2) gene, for its association with genetic risk across a range of anxiety spectrum… CONTINUE READING
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The comorbidity of anxiety and depression in the perspective of genetic epidemiology . A review of twin and family studies

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