Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukaemia.

@article{BoguniaKubik2006LackOA,
  title={Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukaemia.},
  author={Katarzyna Bogunia-Kubik and Grzegorz Mazur and Iwona Urbanowicz and Tomasz P. Wrobel and Kazimierz Kuliczkowski and Mieczysław Woźniak and Andrzej Lange},
  journal={International journal of immunogenetics},
  year={2006},
  volume={33 1},
  pages={21-4}
}
B-cell chronic lymphocytic leukaemia (B-CLL) is a lymphoproliferative disorder characterized by clonal expansion of B lymphocytes. The present study aimed to determine whether there is an association between the polymorphic features located within the promoter/enhancer region of tumour necrosis factor-alpha (TNFA) gene and susceptibility to B-CLL. TNFA (-308 G/A) promoter single nucleotide polymorphism (SNP) was determined by polymerase chain reaction with sequence-specific primers (PCR-SSP… CONTINUE READING

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