Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population

@article{Shi2008LackOA,
  title={Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population},
  author={Dongquan Shi and Haijian Ni and Jin H Dai and Jianghui Qin and Yong Xu and Lunqing Zhu and Chen Yao and Zhenxing Shao and Dongyang Chen and Zhihong Xu and Long Yi and Shiro Ikegawa and Qing Jiang},
  journal={BMC Medical Genetics},
  year={2008},
  volume={9},
  pages={91 - 91}
}
CALM1 gene encodes calmodulin (CaM), an important and ubiquitous eukaryotic Ca2+-binding protein. Several studies have indicated that a deficient CaM function is likely to be involved in the pathogenesis of osteoarthritis (OA). Using a convincing genome-wide association study, a Japanese group has recently demonstrated a genetic association between the CALM1 core promoter polymorphism (-16C/T transition SNP, rs12885713) and OA susceptibility. However, the subsequent association studies failed… CONTINUE READING