Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.

@article{Ulrich2000LackOA,
  title={Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.},
  author={Cornelia M Ulrich and Ellen Kampman and Jeanette Bigler and Stephen M Schwartz and C. -J. Chen and Roberd M Bostick and L. Fosdick and Shirley A. A. Beresford and Yutaka Yasui and John D. Potter},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2000},
  volume={9 4},
  pages={427-33}
}
Colorectal hyperplastic polyps are benign lesions that share many risk factors with colorectal adenomas and cancers. Low folate intakes are associated with an increased risk of colon cancer. The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) may be linked to DNA methylation and nucleotide synthesis and thus play a role in the etiology of colorectal neoplasia. We investigated an association between the common MTHFR polymorphism (C677T) and colorectal hyperplastic polyps within the… CONTINUE READING

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