Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes.

@article{Kumari2005LackOA,
  title={Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes.},
  author={Veena Kumari and Ulrich Ettinger and Trevor Crawford and Elizabeth Shobha Zachariah and Tonmoy Sharma},
  journal={Journal of psychiatric research},
  year={2005},
  volume={39 3},
  pages={227-40}
}
Individuals with schizophrenia, compared to healthy individuals, are known to exhibit deficient prepulse inhibition (PPI) of the startle response as well as reduced performance on the antisaccade task. There is evidence for genetic transmission of both PPI and antisaccadic abnormalities in schizophrenia. It has been suggested that PPI and antisaccade measures identify separate endophenotypes, on the basis of a lack of relationship between PPI and antisaccade deficits in patients with… CONTINUE READING
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