Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.

@article{Malhotra1996LackOA,
  title={Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine.},
  author={Anil K. Malhotra and David Goldman and Norio Ozaki and Alan Breier and Robert W. Buchanan and David Pickar},
  journal={The American journal of psychiatry},
  year={1996},
  volume={153 8},
  pages={1092-4}
}
OBJECTIVE The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. METHOD Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS… CONTINUE READING
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