Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population.

@article{Alp2009LackOA,
  title={Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population.},
  author={Ebru Alp and Sevda Menevşe and Murat Tulmaç and Derya Kan and Rıdvan Yalçın and Aycan Fahri Erkan and Atiye Çengel},
  journal={DNA and cell biology},
  year={2009},
  volume={28 7},
  pages={
          343-50
        }
}
Polymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD… 
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  • Lei Wang, Yi-tong Ma, +11 authors Bao-zhu Wang
  • Biology
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
  • 2012
TLDR
Findings suggest that MMP-9 −1562C>T polymorphism could be associated with the susceptibility to myocardial infarction in Chinese Uighur population, respectively.
Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population.
TLDR
It is suggested that the TT and CT genotypes and T allele of MMP-9 rs3918242 polymorphism is correlated with an increased risk of coronary artery disease in a Chinese population.
Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis
TLDR
An obvious ethnic difference in the association between MMP-9 C1562T polymorphism was significantly related to CAD in East Asians, however, no significant associations were observed in either West Asians or Western populations.
Polymorphism in matrix metalloproteinase-9 1562 C / T contributes to the risk of coronary artery disease
TLDR
It is suggested that the MMP-9 1562 C/T polymorphism is correlated with an increased risk of coronary artery disease in the Chinese population.
The role of matrix metalloproteinase-2 promoter polymorphisms in coronary artery disease and myocardial infarction.
TLDR
This is the first report to detect an association between MMP2 promoter polymorphisms and CAD with or without MI history in the Turkish population and further case-control studies in CAD development might be contributed to clarify the role of these polymorphisms.
Association between matrix metalloproteinase 9 C-1562T polymorphism and the risk of coronary artery disease: an update systematic review and meta-analysis
TLDR
It is suggested that the MMP9 T allele is a risk factor for CAD and MI in Asians and in Caucasians with allelic model and in dominant model.
Association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 and coronary artery disease: a meta-analysis.
TLDR
The meta-analysis supports the fact that -1562C>T polymorphism may have association with CAD risk in Asian populations, but further larger studies are required to confirm the findings.
Lack of association between Glu298Asp polymorphism and coronary artery disease in North Indians
TLDR
The study indicated that Glu298Asp polymorphism does not play any critical role in the pathogenesis of CAD, at least in North Indian population.
Matrix metalloproteinase 9 gene polymorphism 1562C>T is significantly associated with acute coronary syndrome susceptibility in the Vietnamese population
TLDR
The results showed that the MMP-9 1562C>T polymorphism is significantly associated with the ACS susceptibility in the Vietnamese population.
Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms with Coronary Artery Disease: An Updated Meta-Analysis and Systematic Review
TLDR
A systematic review and an updated structured meta-analysis of association of three polymorphic forms of the NOS3 gene with CAD found the Glu298Asp polymorphism showed strongest association, while T786-C and its minor allele seem to carry a highest risk for CAD among subjects of Asian ancestry.
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References

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TLDR
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TLDR
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TLDR
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