Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations.

@article{Asghar2005LackOA,
  title={Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations.},
  author={Tasneem Asghar and Shigeki Yoshida and Satoshi Nakago and Mayumi Morizane and Norita Ohara and Satoru Motoyama and Stephen H. Kennedy and David H Barlow and Takeshi Maruo},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={2005},
  volume={20 2},
  pages={59-63}
}
Endometriosis is a complex trait, which means that multiple susceptibility genes interact with one another and the environment to produce the phenotype. One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays a vital role in steroid biosynthesis in the ovary. The presence of a single nucleotide… CONTINUE READING