Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis.

@article{Manuel2009LackOA,
  title={Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis.},
  author={Oriol Manuel and Deepali Kumar and George Moussa and Maggie Hong Chen and Joseph W Pilewski and K R. Mccurry and Sean M. Studer and M. Francisco Rivas Crespo and S Hamid Husain and Atul Humar},
  journal={Transplantation},
  year={2009},
  volume={87 5},
  pages={719-25}
}
BACKGROUND Cytomegalovirus (CMV), human herpesvirus-6 and -7 (HHV-6 and -7) are beta-herpesviruses that commonly reactivate and have been proposed to trigger acute rejection and chronic allograft injury. We assessed the contribution of these viruses in the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation. METHODS Quantitative real-time polymerase chain reaction of bronchoalveolar lavage samples were performed for CMV, HHV-6 and -7 in a prospective cohort of… CONTINUE READING