Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritis.

@article{PontKingdon2009LackOA,
  title={Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritis.},
  author={Genevi{\`e}ve A. Pont-Kingdon and John Bohnsack and Kelli L. Sumner and April A. Whiting and Bronte Clifford and Stephen Guthery and Lynn B. Jorde and Elaine Lyon and Sampath Prahalad},
  journal={Scandinavian journal of rheumatology},
  year={2009},
  volume={38 2},
  pages={91-5}
}
OBJECTIVE Juvenile idiopathic arthritis (JIA) is a chronic autoimmune arthropathy. Beta 2-adrenergic receptors are a link between the sympathetic nervous system and the immune system. Associations between variants in the gene encoding the beta 2-adrenergic receptor (ADRB2) and autoimmune disorders such as rheumatoid arthritis (RA) have been demonstrated. We aimed to investigate ADRB2 variants for association with JIA. METHODS Genotypes and haplotypes of two ADRB2 variants (G16R and Q27E) were… CONTINUE READING