Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease.

@article{Kunicki2008LackOA,
  title={Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease.},
  author={Thomas James Kunicki and Shirley A. Williams and Diane Jean Nugent and Paul J Harrison and Helen C. Segal and Anila Syed and Peter M. Rothwell},
  journal={Thrombosis and haemostasis},
  year={2008},
  volume={101 1},
  pages={
          123-33
        }
}
We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function Analyzer-100 (PFA-100). We correlated ASA responsiveness with haplotypes of seven candidate genes, selected for their documented role in platelet function, namely, the genes for integrins alpha2beta1and alphaIIbbeta3 (ITGA2, ITGA2B, and ITGB3), platelet glycoproteins Ibalpha and VI (GPIBA and… CONTINUE READING

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