Lack of association between SLCO1B1 polymorphism and the lipid-lowering effects of atorvastatin and simvastatin in Chinese individuals

@article{Fu2012LackOA,
  title={Lack of association between SLCO1B1 polymorphism and the lipid-lowering effects of atorvastatin and simvastatin in Chinese individuals},
  author={Qiang Fu and Yanpeng Li and Yuan Gao and Song-hua Yang and Pei-Qi Lu and Min Jia and Lirong Zhang},
  journal={European Journal of Clinical Pharmacology},
  year={2012},
  volume={69},
  pages={1269-1274}
}
There is significant inter-individual variability in the lipid-lowering effects of atorvastatin and simvastatin. Our goal was to investigate the impact of SLCO1B1 genetic polymorphism on the lipid-lowering effects of atorvastatin and simvastatin. We recruited 363 unrelated hyperlipidemic patients with the CYP3A4*1/*1, CYP3A5*1/*1, and CYP3AP1*1/*1 genotypes: 189 of these were treated with atorvastatin and 174 were treated with simvastatin as a single-agent therapy (20 mg day−1 orally) for 4… CONTINUE READING
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