Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-D-fructofuranose in the male rat.

@article{Jones2002LackOA,
  title={Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-D-fructofuranose in the male rat.},
  author={A. Jones and C. Morin and W. Bone and T. G. Cooper},
  journal={International journal of andrology},
  year={2002},
  volume={25 3},
  pages={
          168-74
        }
}
  • A. Jones, C. Morin, +1 author T. G. Cooper
  • Published 2002
  • Biology, Medicine
  • International journal of andrology
  • The antifertility action of (R,S)-alpha-chlorohydrin administered orally to male rats was compared with that of several novel chlorinated compounds known to inhibit glycolysis and the kinematics of rat sperm in vitro. Oral gavage of 1,6-dichloro-1,6-dideoxy-D-fructofuranose (dichlorodideoxyfructose, DCF), 1-chloro-3-hydroxypropanone, its dimethylketal and bromopyruvate did not reduce the fertility of male rats below that of controls at the equivalent antifertility dose of (R,S)-alpha… CONTINUE READING
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