Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.

@article{Gut2005LackOA,
  title={Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.},
  author={Philipp Gut and Katrin Huber and Jennifer Lohr and Barbara Br{\"u}hl and Stephan Oberle and Mathias Treier and Uwe Ernsberger and Chaya Kalcheim and Klaus Unsicker},
  journal={Development},
  year={2005},
  volume={132 20},
  pages={4611-9}
}
The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin cells was thought to be largely understood. In-vitro studies with isolated SA progenitor cells had suggested that chromaffin cell differentiation depends crucially on glucocorticoids provided by adrenal cortical cells. However, analysis of mice lacking the glucocorticoid receptor gene had revealed that adrenal chromaffin cells develop mostly normally… CONTINUE READING